BernheimV1, Main, Exploration, bibRecord, 000076

Molecular characterization of hepatocellular carcinoma related to hepatitis B virus

Identifieur interne : 000076 ( Main/Exploration ); précédent : 000075; suivant : 000077

Molecular characterization of hepatocellular carcinoma related to hepatitis B virus

Auteurs : Qian Cao [France]

Source :

RBID : Hal:tel-01126915

Descripteurs français

mix :
- Carcinome hépatocellulaire, Gène onco-fœtal, HBx, SNPs, TP53, Virus de l’hépatite B.

English descriptors

mix :
- Hepatitis B virus, Hepatocellular carcinoma, Onco-fœtal gene.

Abstract

Hepatocellular carcinoma (HCC) is the most common primary liver tumors. Hepatic carcinogenesis is a complex and multifactorial process involving both genetic predisposition (e.g. SNPs) and environmental factors. Nearly 50% of HCC are caused by the hepatitis B virus (HBV) infection worldwide. During HBV infection, multiple genetic and viral alterations accumulate and promote tumor development. By analyzing resected HCC in France, we identified specific molecular features related to HBV infection. First, HBx inactivating mutations are selected in HCC tissues suggesting specific pressure of selection during hepatocarcinogenesis. Second, in patients with a low number of HBV DNA copies per liver cell, we identified additional risk factors like HCV infection, alcohol intake or NASH, suggesting a cooperative effect of these factors with HBV to induce the malignant transformation. Third, TP53 mutations associated with a poor prognostic for HBV infected resected HCC patients. At last, HBV-related tumors demonstrate more frequent progenitor phenotype compared to non-HBV HCC, with an up-regulation of genes that involved in cell cycle regulation and encoded onco-fetal/progenitor proteins. Four SNPs previously identified by genome-wide studies (GWAS) in Asian, have been validated in our European population. Allelic distributions seem to vary according to the etiologies of adjacent liver diseases. These findings underscore the complexity of the genetic predisposition of HCC; further study must consider the geographical origin of patients and associated risk factors.

Url:

https://tel.archives-ouvertes.fr/tel-01126915

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000099
to stream Hal, to step Curation: 000099
to stream Hal, to step Checkpoint: 000070
to stream Main, to step Merge: 000076
to stream Main, to step Curation: 000076

Le document en format XML

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<front><div type="abstract" xml:lang="en">Hepatocellular carcinoma (HCC) is the most common primary liver tumors. Hepatic carcinogenesis is a complex and multifactorial process involving both genetic predisposition (e.g. SNPs) and environmental factors. Nearly 50% of HCC are caused by the hepatitis B virus (HBV) infection worldwide. During HBV infection, multiple genetic and viral alterations accumulate and promote tumor development. By analyzing resected HCC in France, we identified specific molecular features related to HBV infection. First, HBx inactivating mutations are selected in HCC tissues suggesting specific pressure of selection during hepatocarcinogenesis. Second, in patients with a low number of HBV DNA copies per liver cell, we identified additional risk factors like HCV infection, alcohol intake or NASH, suggesting a cooperative effect of these factors with HBV to induce the malignant transformation. Third, TP53 mutations associated with a poor prognostic for HBV infected resected HCC patients. At last, HBV-related tumors demonstrate more frequent progenitor phenotype compared to non-HBV HCC, with an up-regulation of genes that involved in cell cycle regulation and encoded onco-fetal/progenitor proteins. Four SNPs previously identified by genome-wide studies (GWAS) in Asian, have been validated in our European population. Allelic distributions seem to vary according to the etiologies of adjacent liver diseases. These findings underscore the complexity of the genetic predisposition of HCC; further study must consider the geographical origin of patients and associated risk factors.</div>
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Serveur d'exploration Hippolyte Bernheim

Molecular characterization of hepatocellular carcinoma related to hepatitis B virus

Molecular characterization of hepatocellular carcinoma related to hepatitis B virus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri